A three-alarm fire tore through a multi-story Hillcrest commercial building today, causing extensive damage and forcing the closure of traffic lanes in the busy area.

The United States has agreed to comply with its NAFTA obligations in return for a lift on tariffs.

Home Post Blog: A helicopter crash at Camp Pendleton left one Marine dead and five others injured.

Thousands of healthy San Diego seniors are participating in a provocative genome study to find the root cause of heart disease.

Networks and cable news stations stopped regular programming yesterday, as the nation watched the verdict of the Casey Anthony murder trial. Why do some trials and criminal cases grab national attention? Does the media feed the frenzy or just follow it?

What were the early years of HIV/AIDS like in San Diego? How has our view of HIV/AIDS changed over the last 30 years, and what are the greatest current challenges to preventing the spread of the deadly disease? We speak to KPBS Health Reporter Kenny Goldberg about his three-part series on the HIV/AIDS pandemic.

The Padres are as hot as local temperatures right now, but will their winning ways last through the summer? We speak to Sports Columnist Jay Paris about the Padres recent success, the NFL Lockout, and how the Aztecs football team is shaping up for next season.

Thousands of aspiring singers were expected to flock to Petco Park in downtown San Diego today to register for an audition for the11th season of "American Idol.''

The border is rife with rumors of spillover violence from Mexico's drug war. But what's real?

San Diego public school students are scoring higher on state English and math tests, but the achievement gap for African-American and Hispanic students persists. The school district is starting an effort focused specifically on improving African and African-American students’ school performance.

Sacramento may know how much it plans to spend in the new fiscal year. But that doesn’t mean it’s clear yet how much money San Diego Unified can count on to operate schools.

It's been 30 years since the first cases of AIDS emerged. Since then, the disease has killed nearly 7,300 people in San Diego, and the human toll continues to mount.