As we've reported all week, the first part of disgraced cyclist Lance Armstrong's confessional with talk show host Oprah Winfrey airs Thursday night.

HIV treatment is most beneficial when it's started within four months of the estimated infection date, according to a new study.

Host Christopher Kimball heads into the test kitchen with test cook Bridget Lancaster to uncover the secrets to the ultimate Carrot Layer Cake. Next, equipment expert Adam Ried tests springform pans in the Equipment Corner. And finally, test cook Julia Collin Davison reveals how to make the best Peanut Butter Sandwich Cookies.

Technical problems with their Boeing 787 aircraft have caused Japan Airlines to cancel even more of its direct flights from San Diego to Tokyo.

Are the CEOs of mega-banks too big to jail? Though fraudulent practices at banks contributed to America’s financial meltdown, to date no Wall Street titan has been convicted of a crime connected to the crisis. FRONTLINE investigates why Wall Street’s leaders have escaped prosecution.

Tougher border security in San Diego has driven would-be border crossing migrants east, to the deserts of Arizona and Texas.

The construction industry in the U.S. is staging a comeback. In one indicator, the Commerce Department announced Thursday that new homebuilding has reached its highest level in 4 1/2 years.

There’s one spot available, roughly two months to campaign, and, so far, 14 potential candidates for San Diego’s District 4 City Council seat.

A recent study has found unlicensed drivers are nearly three times more likely to cause a fatal crash than drivers with valid licenses.

A person was fatally shot by a San Diego police officer near San Diego State University Thursday, and authorities have taken one person into custody following lengthy standoff and search.

The Aurora, Colo., theater where 12 people were killed in a mass shooting last summer reopens Thursday, with a private event for victims' families and first responders.

An entire school of teachers in Seattle is refusing to give students a standardized test that's required by the district. The teachers say the test is useless and wastes valuable instructional time.

Advanced Placement exams, which many high school students use to gain course credits when they attend college, will no longer be accepted for credit at Dartmouth College, the Associated Press reports.

The Force will be with Marines and their families Friday evening at MCAS Miramar, as the USO hosts two private screenings of the Cartoon Network series "Star Wars: The Clone Wars."

Nearly three years after a deadly mine explosion in West Virginia, a former Massey Energy mine superintendent has been sentenced to prison and federal regulators have toughened a regulation that could have helped prevent the disaster.

There's plenty on offer this weekend to satiate your belly and your ears. From food and wine, to live Afrobeat and jazz, here are some ideas on how to enjoy your weekend to the fullest.

Pauline Phillips, known to millions of advice-seekers around the world as the original "Dear Abby," has died. She was 94.

If disgraced cyclist Lance Armstrong's confession to doping is as complete as many believe, the admission could increase his legal troubles after Oprah Winfrey's OWN TV airs the interview Thursday night.

The non-partisan Equinox Center released its fourth annual “Dashboard” report that highlights important trends affecting our quality of life in the San Diego region.

The Pentagon won't intervene in the decision by a military spouses club to deny membership to the wife of a lesbian soldier.

When I discovered I was pregnant I realized it was time for a change of pace. I'd been covering conflicts around the world for 12 years. The plan was to retreat to balmy Miami where my family is, have my baby and just slow down for a bit.

When I was diagnosed with breast cancer two years ago, it was clear that I would be thinking about a lot of things -- myriad doctor visits, multiple tests, surgeries and chemotherapy.

A Marine recruit from MCRD San Diego was arrested this morning after allegedly running across the airport runway at Lindbergh Field.

After huge critical and commercial success last year, breakthrough British sensation Emeli Sande has her sights set on America.

The U.S. Navy minesweeper USS Guardian ran aground on a coral reef off the coast of the Philippines early Thursday morning. The USS Guardian is based in Sasebo, Japan.

Editor's note: Our partner GlobalPost is launching a series that looks at wealth and poverty worldwide by comparing U.S. metro areas with foreign cities that have similar levels of income inequality. The findings may surprise you. This story from Fairfield County, Conn., and a companion piece from Bangkok, examine two places where the superrich and the very poor live just minutes apart.

If you're trying to make sense of the news that Notre Dame football star Manti Te'o now says he was the victim of a hoax and that the woman he thought was his "girlfriend" never existed and never died, you'll want to read an Oct. 12 story published by the South Bend Tribune.

The Border Patrol says arrests in the San Diego region last year fell by about one-third to its lowest level in more than four decades.

There's a California population shift with Asian immigrants replacing Latin America as the primary source of the state's immigrants.

The Nuclear Regulatory Commission is considering a petition from groups who say Southern California Edison failed to get proper approval before replacing San Onofre’s steam generators. The faulty generators led to the shut down of the nuclear plant a year ago.

An ambitious goal to reduce the use of fossil fuels looks to algae as a way to power the fleet.

The city has instituted four of 10 recommendations and are in the process of implementing four others, according to a report that had been scheduled to go before the committee.

Maria Peyer and Mike Bixby are one of those couples who just seem made for each other. They hold hands when they sit and talk. They're happy to spend the morning cooking brunch with their children in their home in southern Washington.

This is the second of a two-part discussion. Read Part 1.

Dr. Beth Zeeman says she can spot a case of influenza from 20 paces. It's not like a common cold.