Defective BRCA1 causes aberrant expression of non-coding satellite RNA that leads to genomic instability, thereby promoting cancer development. The image shows that over-production of satellite RNA leads to abnormal number of centrosomes in a normal human epithelial cell.
Centrosomes are pictured in red, tublin in green and chromosomes in blue. The "mirrored" image in the Sputnik satellite is a confocal microscopic image.
Center: a mathematical reconstruction of the confocal image to resolve the tubulin fibers and the individual chromosomes.
Published on September 8, 2011