skip to main content

Listen

Read

Watch

Schedules

Programs

Events

Give

Account

Donation Heart Ribbon

Avatar for Lowell

( Lowell )

Comments made by Lowell

Vaccine Refusals Fueled California's Whooping Cough Epidemic

Nonhuman Primate Model of Pertussis

Our results demonstrate that the baboon provides an excellent model of clinical pertussis that will allow researchers to investigate pertussis pathogenesis and disease progression, evaluate currently licensed vaccines, and develop improved vaccines and therapeutics.

http://iai.asm.org/content/80/4/1530....

Pertussis Vaccine Study Shatters Illusion of Vaccine-Induced Immunity
http://articles.mercola.com/sites/art...

Global Population Structure and Evolution of Bordetella pertussis and Their Relationship with Vaccination

Abstract excerpt: We observed that changes in genes encoding proteins implicated in protective immunity that are included in ACVs occurred after the introduction of WCVs but before the switch to ACVs. Furthermore, our analyses consistently suggested that virulence-associated genes and genes coding for surface-exposed proteins were involved in adaptation. However, many of the putative adaptive loci identified have a physiological role, and further studies of these loci may reveal less obvious ways in which B. pertussis and the host interact. This work provides insight into ways in which pathogens may adapt to vaccination and suggests ways to improve pertussis vaccines.

IMPORTANCE Whooping cough is mainly caused by Bordetella pertussis, and current vaccines are targeted against this organism. Recently, there have been increasing outbreaks of whooping cough, even where vaccine coverage is high. Analysis of the genomes of 343 B. pertussis isolates from around the world over the last 100 years suggests that the organism has emerged within the last 500 years, consistent with historical records. We show that global transmission of new strains is very rapid and that the worldwide population of B. pertussis is evolving in response to vaccine introduction, potentially enabling vaccine escape.

Read more:
http://mbio.asm.org/content/5/2/e0107...

This means that pertussis vaccination has caused the pertussis bacteria to mutate and develop and the new whooping cough is now more lethal than the natural one because the mutated pertussis generates more toxins.

June 27, 2014 at 5:02 p.m. ( | suggest removal )

Vaccine Refusals Fueled California's Whooping Cough Epidemic

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model

Significance

Pertussis has reemerged as an important public health concern since current acellular pertussis vaccines (aP) replaced older whole-cell vaccines (wP). In this study, we show nonhuman primates vaccinated with aP were protected from severe symptoms but not infection and readily transmitted Bordetella pertussis to contacts. Vaccination with wP and previous infection induced a more rapid clearance compared with naïve and aP-vaccinated animals. While all groups possessed robust antibody responses, key differences in T-cell memory suggest that aP vaccination induces a suboptimal immune response that is unable to prevent infection. These data provide a plausible explanation for pertussis resurgence and suggest that attaining herd immunity will require the development of improved vaccination strategies that prevent B. pertussis colonization and transmission.

Abstract
Pertussis is a highly contagious respiratory illness caused by the bacterial pathogen Bordetella pertussis. Pertussis rates in the United States have been rising and reached a 50-y high of 42,000 cases in 2012. Although pertussis resurgence is not completely understood, we hypothesize that current acellular pertussis (aP) vaccines fail to prevent colonization and transmission. To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with B. pertussis at 7 mo. Infection was followed by quantifying colonization in nasopharyngeal washes and monitoring leukocytosis and symptoms. Baboons vaccinated with aP were protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted B. pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity. Previously infected animals and wP-vaccinated animals possess strong B. pertussis-specific T helper 17 (Th17) memory and Th1 memory, whereas aP vaccination induced a Th1/Th2 response instead. The observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccines.

Read more:
http://www.pnas.org/content/early/201...

June 27, 2014 at 5:01 p.m. ( | suggest removal )

Vaccine Refusals Fueled California's Whooping Cough Epidemic

Big Surprise - Whooping Cough Spreads Mainly through Vaccinated Populations
81 Percent of Whooping Cough Cases Occurred in People Who Were Fully Vaccinated
http://articles.mercola.com/sites/art...

Whooping cough vaccine fades in pre-teens: study

I also noticed that under Results in the abstract it lists vaccine effectiveness was 41%, 24%, and 79% for children aged 2–7 years, 8–12 years, 13–18 years, respectively. That as well does not seem to be real good, nor very impressive. Thus indeed that figure of 81% in the outbreak that were found to be fully vaccinated and up to date, would have likely been quite predicable and probable. (Abstract link below)

Excerpts:

"We have a real belief that the durability (of the vaccine) is not what was imagined," said Dr. David Witt, an infectious disease specialist at Kaiser Permanente Medical Center in San Rafael, California, and senior author of the study.

The pertussis vaccine, a five-shot series referred to as DTaP, is recommended for children at ages two-, four-, six- and 18-months, and at four to six years old.

The CDC recommends that at age 11 or 12 kids get the booster shot called Tdap.

In early 2010, a spike in cases appeared at Kaiser Permanente in San Rafael, and it was soon determined to be an outbreak of whooping cough -- the largest seen in California in more than 50 years.

Witt had expected to see the illnesses center around unvaccinated kids, knowing they are more vulnerable to the disease.

"We started dissecting the data. What was very surprising was the majority of cases were in fully vaccinated children. That's what started catching our attention," said Witt.

To figure out just how well the vaccine was working, Witt and his colleagues collected information on every patient who had tested positive for pertussis between March and October, 2010.

Of the 132 patients under age 18, 81 percent were up to date on recommended whooping cough shots and eight percent had never been vaccinated. The other 11 percent had received at least one shot, but not the complete series.

The rate of cases for each age, two through 18 years old, peaked among kids in their pre-teens.

Read more:
http://www.reuters.com/article/2012/0...

June 27, 2014 at 5 p.m. ( | suggest removal )

Vaccine Refusals Fueled California's Whooping Cough Epidemic

Arch Dis Child. Aug 2003; 88(8): 684–687.
doi: 10.1136/adc.88.8.684
PMCID: PMC1719607
Clinical and epidemiological picture of B pertussis and B parapertussis infections after introduction of acellular pertussis vaccines

Results: There were 180 Bordetella infections; 116 (64%) were caused by B pertussis and 64 (36%) by B parapertussis. Incidence rates were 4.8 and 2.8 per 1000 person-years, respectively. Paroxysmal cough, post-tussive whooping, and vomiting ≥21 days was found in 53%, 22%, and 8% of all B pertussis cases and in 22%, 5%, and 0% of all B parapertussis cases, respectively. A total of 81/116 (70%) B pertussis cases and 56/64 (87.5%) B parapertussis cases had received at least one dose of pertussis vaccine. Typical pertussis with paroxysmal cough ≥21 days was present in 29/35 (83%) unvaccinated B pertussis cases, in contrast to 33/81 (41%) vaccinated B pertussis cases.

Conclusion: Following the increase of pertussis vaccination coverage, we observed a relative increase of B parapertussis cases in comparison to B pertussis cases. In vaccinated children B pertussis disease frequently presented as a mild disease, clinically difficult to distinguish from diseases associated with coughing caused by B parapertussis and other viral or bacterial infections.

http://www.ncbi.nlm.nih.gov/pmc/artic...

2013 Provisional Pertussis Surveillance Report
​2,570 listed cases of acquiring pertussis after 3 plus doses of B pertussis vaccine. Another 343 cases after 1 to 2 doses of vaccine.
http://www.cdc.gov/pertussis/download...

Whooping Cough Outbreak- Largest in 50 yrs

Its all over the news, the internet and the newspapers. Largest whooping cough outbreak in 5 decades....go get vaccinated and protect your children...oh my...thats the LAST THING you should do. Heres why.

http://www.educate4theinjured.org/#!p...

And why are we additionally having measles outbreaks where 90% were fully vaccinated?

Why is the CDC and FDA Still Recommending the Failed Whooping Cough Vaccine?
http://healthimpactnews.com/2014/why-...

The Measles Vaccine Failure the U.S. Media is not Covering
http://healthimpactnews.com/2014/the-...

The 2013 Measles Outbreak: A Failing Vaccine, Not A Failure To Vaccinate
http://www.greenmedinfo.com/blog/2013...

June 27, 2014 at 4:10 p.m. ( | suggest removal )

Vaccine Refusals Fueled California's Whooping Cough Epidemic

Whooping Cough Vaccine Does Not Work – Says US FDA’s Research

The abstract of the paper states:

Baboons vaccinated with aP were protected from severe pertussis-associated symptoms but not from colonization, did not clear the infection faster than naïve animals, and readily transmitted B. pertussis to unvaccinated contacts. Vaccination with wP induced a more rapid clearance compared with naïve and aP-vaccinated animals. By comparison, previously infected animals were not colonized upon secondary infection. Although all vaccinated and previously infected animals had robust serum antibody responses, we found key differences in T-cell immunity. Previously infected animals and wP-vaccinated animals possess strong B. pertussis-specific T helper 17 (Th17) memory and Th1 memory, whereas aP vaccination induced a Th1/Th2 response instead. The observation that aP, which induces an immune response mismatched to that induced by natural infection, fails to prevent colonization or transmission provides a plausible explanation for the resurgence of pertussis and suggests that optimal control of pertussis will require the development of improved vaccines.”

http://childhealthsafety.wordpress.co...

Acellular pertussis vaccination enhances B. parapertussis colonization

An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade.

http://www.ncbi.nlm.nih.gov/pubmed/20...

http://www.cidd.psu.edu/research/syno...

Rapid Increase in Pertactin-deficient Bordetella pertussis Isolates, Australia

Abstract
Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008–2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (prn). Multiple mechanisms of prn inactivation were documented, including IS481 and IS1002 disruptions, a variation within a homopolymeric tract, and deletion of the prn gene. The mechanism of lack of expression of prn in 16 (17%) isolates could not be determined at the sequence level. These findings suggest that B. pertussis not expressing prn arose independently multiple times since 2008, rather than by expansion of a single prn-negative clone. All but 1 isolate had ptxA1, prn2, and ptxP3, the alleles representative of currently circulating strains in Australia. This pattern is consistent with continuing evolution of B. pertussis in response to vaccine selection pressure.

http://wwwnc.cdc.gov/eid/article/20/4...

June 27, 2014 at 4:10 p.m. ( | suggest removal )

Vaccine Refusals Fueled California's Whooping Cough Epidemic

Actually the evidence is certainly sufficient to conclude that there are obviously major vaccine failures going on with both pertussis, and measles vaccine. Instead of the CDC being forth right as to that information; first they start cocoon style vaccinating entire families, which failed; so then they start in with the push to vaccinate with an aluminum adjuvant containing Tdap vaccine, every pregnant woman everywhere and every adult that will allow themselves to be. And its still failing.

Warning to Pregnant Mothers - Toxic Dose of Aluminum in the Tdap, by Paul Thomas, Pediatrician
https://www.youtube.com/watch?v=VoY6v...

The Current Failure of Pertussis and Measles Vaccine
http://www.vacfacts.info/the-current-...

How can they claim to that vaccinating would prevent pertussis in a newborn or those to young to be vaccinated when their was a well known baboon study recently that conclusively proves that the vaccinated can and do still spread the pathogen when exposed and challenged; even though they may remain asymptomatic. To my knowledge this does not happen when immune to pertussis through natural infection. So, why are they not doing the long overdue studies such as this baboon study, in regard to all vaccines. That would be real science in regard to vaccines.

They more than likely have evaded such studies because the possible findings just may bring about a conclusion that the only way to eradicate these illnesses, is through natural immunity. There goes your toxic and contaminated vaccine program, and all its profits.

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
http://www.pnas.org/content/early/201...

Pertussis Vaccine Study Shatters Illusion of Vaccine-Induced Immunity
http://articles.mercola.com/sites/art...

Nonhuman Primate Model of Pertussis

Our results demonstrate that the baboon provides an excellent model of clinical pertussis that will allow researchers to investigate pertussis pathogenesis and disease progression, evaluate currently licensed vaccines, and develop improved vaccines and therapeutics.

http://iai.asm.org/content/80/4/1530....

June 27, 2014 at 4:09 p.m. ( | suggest removal )

Immunized People Getting Whooping Cough

Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model
http://www.pnas.org/content/early/201...

In this above baboon study, pertussis vaccine was shown to not prevent transmission of the pertussis pathogen, in the vaccinated; even though being challenged and remaining non symptomatic. So then, how is it possible that the claim is true that vaccination protects the unvaccinated, or those that can not be vaccinated? Obviously it does not. Why did they not do that kind of a study years ago, and as well in regard to all vaccines given? You see some of the most important issues have been overlooked; and but yet you people all present with that you are the purveyors of the needed vaccine safety and effectiveness science. They need to do this same study in regard to all vaccines, and why haven't they? Then do a study as well in comparison where naturally immune persons, and/or baboons are studied to see if they shed the pathogen while remaining asymptomatic? Now, that would not be likely, would it; so lets once and for all do the study.

The CDC would be fearful of the result of such a study, as it would very likely show that the only possible way to eradicate these illness is through natural immunity. This would be the real vaccine effectiveness science which they have obviously neglected to do.

Acellular pertussis vaccination enhances B. parapertussis colonization

An acellular whooping cough vaccine actually enhances the colonization of Bordetella parapertussis in mice; pointing towards a rise in B. parapertussis incidence resulting from acellular vaccination, which may have contributed to the observed increase in whooping cough over the last decade.

http://www.ncbi.nlm.nih.gov/pubmed/20...

http://www.cidd.psu.edu/research/syno...

June 27, 2014 at 3:23 p.m. ( | suggest removal )

Immunized People Getting Whooping Cough

How many times Dorit Reiss, must a vaccine repeatedly fail before such as the CDC admits to that failure, and as well that vaccine derived herd immunity has NOT worked?

Why is the CDC and FDA Still Recommending the Failed Whooping Cough Vaccine?
http://healthimpactnews.com/2014/why-...

The Measles Vaccine Failure the U.S. Media is not Covering
http://healthimpactnews.com/2014/the-...

Researchers find first US evidence of vaccine-resistant pertussis
http://www.cidrap.umn.edu/news-perspe...

Pertussis Vaccine Failure is not Just Modern but Historical: the Vaccine has Never Been Effective
http://healthimpactnews.com/2013/pert...

Failed Vaccines Become Public Health Crisis
http://healthimpactnews.com/2014/fail...

Researchers find first US evidence of vaccine-resistant pertussis
http://healthimpactnews.com/2013/rese...

The Current Failure of Pertussis and Measles Vaccine
http://www.vacfacts.info/the-current-...

Mass vaccination advocates rely on ‘herd immunity’ to make their case. But it doesn’t exist

Cracked beaker“When vaccination rates are very high, as they still are in the nation as a whole, everyone is protected,” explained USA Today in a recent editorial entitled “Vaccine opt-outs put public health at risk.”

“This ‘herd immunity’ protects the most vulnerable, including those who can’t be vaccinated for medical reasons, infants too young to get vaccinated and people on whom the vaccine doesn’t work. But herd immunity works only when nearly the whole herd joins in. When some refuse vaccinations and seek a free ride, immunity breaks down and everyone is more vulnerable.”

The concept of “herd immunity” first materialized in the 1930s, when Johns Hopkins University’s Arthur Hedrich discovered that, after 55% of Baltimore’s population acquired measles (and thus immunity to measles), the rest of the population, or “herd,” became protected. This concept provides today’s rationale for insisting that everyone be vaccinated.

Measles outbreaks occur even when the vaccinated population exceeds 95%

“If you only risked your own health by not getting vaccinated, that would be your business,” mass vaccination advocates state. “But when your failure to get vaccinated endangers me or my child, that becomes my business.” It’s a powerful argument, except for one thing — herd immunity in vaccinated populations has been repeatedly disproven.

Read more:
http://business.financialpost.com/201...

June 27, 2014 at 3:22 p.m. ( | suggest removal )

Shot Delays: Alternative Vaccine Schedules Mean Fewer San Diego Students Are Fully Immunized

To claim that Wakefield's study was largely discredited is to ignore the large number of studies that support the findings of that study and as well nearly duplicate the study and with the same findings. The successes of biomedical treatment in the reversal of ASD and with as well dietary changes that clearly heal the live MMR vaccine damaged intestinal tract and bowel, that in itself is siding with the side of selective ignorance and denial.

How do they explain that with the major increase in vaccines that children are now sicker than they have ever been in history. Children with more illness and chronic disorders than ever before. You will not find this in the families with unvaccinated children. We have to realize as well the major discrepancy in the vaccine history of success that the CDC tells of us, verses the real history that was recorded by individuals and doctors in the actual time frames of existing and past outbreaks of such as small pox and polio. The real story of vaccine failure is nothing like the majorly false propaganda that we are and have been fed. It is time to wake up and realize clearly the major amount of misinformation we have been fed.

Callous Disregard-Research, (more studies confirming that Dr Andrew Wakefield's 1998 study, was correct)
http://www.callous-disregard.com/rese...

August 31, 2013
New Published Study Verifies Andrew Wakefield’s Research on Autism – Again

Controversial Doctor and Autism Media Channel Director proven right - MMR Vaccine Causes Autism & Inflammatory Bowel Disease
http://healthimpactnews.com/2013/new-...

Dr Andrew Wakefield - MMR Vaccine - Truth and Reality
http://www.vacfacts.info/dr-andrew-wa...

The Independent Science Showing the Harm of Vaccines and the Connection to ASD
http://antivaccine.wordpress.com/2012...

The Unbiased Vaccine Science and Data
http://www.vacfacts.info/the-unbiased...

Vaccine Contamination
http://www.vacfacts.info/vaccine-cont...

Aluminum Adjuvants - Lack of Safety Data - Lack of Aluminum Adjuvant Safety Studies
http://www.vacfacts.info/aluminum-vac...

The False Theory of Vaccine Derived - Herd Immunity
http://www.vacfacts.info/the-false-th...

September 19, 2013 at 10:34 p.m. ( | suggest removal )