Skip to main content

LATEST UPDATES: Tracking COVID-19 | Racial Justice | Election 2020

San Diego Scientists Develop New Way Of Looking Deep Inside The Human Brain

Photo by Nicholas McVicker

Gwendolyn Kaeser, co-author of a new study identifying differences in gene expression among cells throughout the human brain, holds up a microscope slide, June 23, 2016.

By zooming inside individual neurons from different brain regions, scientists found diversity in how different cells transcribe their DNA.

A team of San Diego scientists has developed a new way of looking deep into the human brain. By zooming inside individual cells from different brain regions, researchers found diversity in how different neurons transcribe their DNA.

For a study published in the journal Science on Thursday, the scientists looked at the genes expressed in different neurons from six different regions of a postmortem human brain. Based on the genetic activity found within these cells, they were able to identify 16 different subtypes of neurons.

"This was a chance to look at single neurons in a way that really hadn't been possible before on a large scale," said Jerold Chun, a neuroscientist at the Scripps Research Institute in La Jolla and a senior author of the study.

"We've known for many years that there are huge differences in the way neurons look and how they're connected," he said. "But now we can actually look at some of the molecules that are responsible for that."

Chun says understanding diversity among neurons will be important for understanding diseases like Alzheimer's and Parkinson's.

Genetic studies of human brain cells have been done in the past, but they've focused on isolated chunks of surgically removed brain. Chun says that's like looking at a small American neighborhood and assuming it represents all of the diversity found throughout the U.S.

So far, the technique has only been applied to one brain donated by a 51-year-old woman free of neurodegenerative disease. Chun hopes to create a reference map of the genetic diversity found in a typical, healthy brain. That will require probing a lot more regions within a lot more human brains.

Scientists from UC San Diego and the local gene sequencing company Illumina also worked on the study.

"We couldn't have done it without this incredible collaboration," Chun said. "I think that's one of the great strengths of the community here."

FEATURED PODCAST

San Diego News Matters podcast branding

KPBS' daily news podcast covering local politics, education, health, environment, the border and more. New episodes are ready weekday mornings so you can listen on your morning commute.

  • Need help keeping up with the news that matters most? Get the day's top news — ranging from local to international — straight to your inbox each weekday morning.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Curious San Diego banner

Want more KPBS news?
Find us on Twitter and Facebook, or sign up for our newsletters.

To view PDF documents, Download Acrobat Reader.