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NOVA: Human Nature

Airs Wednesday, Sept. 9, 2020 at 8 p.m. on KPBS TV + Sunday, Sept. 13 at 8 p.m. on KPBS 2 + Stream with the PBS Video App

CAS-9 is a powerful protein that acts like a pair of molecular scissors, capa...

Credit: Courtesy of Ned Piyadarakorn

Above: CAS-9 is a powerful protein that acts like a pair of molecular scissors, capable of cutting strands of DNA in precise locations in the genome so that the DNA can be edited.

NOVA INVESTIGATES THE HISTORY AND DEVELOPMENT OF REVOLUTIONARY GENE-EDITING TECHNOLOGY

On Sept. 9, 2020, NOVA will premiere “Human Nature,” a new feature-length film exploring the science, history, and ethics of a revolutionary gene-editing technology and its applications.

“Human Nature” follows the story of scientific developments in gene therapy, culminating in our ability to make precise edits to DNA—including human DNA. The film tells the story of the discovery of CRISPR CAS-9 editing, which has shown early promise as a cure for several debilitating or lethal genetic diseases, but also has the capability of making changes to healthy genes—raising ethical questions about whether we should be altering human DNA at all.

“CRISPR is a world-changing technology that raises essential ethical questions about health care, equitable access to medical breakthroughs, and even our future as a species,” says NOVA Co-Executive Producer, Chris Schmidt. “As one of America’s most-trusted science documentary series, we are so proud to present this important story to the public.”

NOVA: Human Nature: Sneak Peek

With an extraordinary new technology called CRISPR, we can now edit DNA—including human DNA. But how far should we go? Gene-editing promises to eliminate certain genetic disorders like sickle cell disease. But the applications quickly raise ethical questions. Is it wrong to engineer soldiers to feel no pain, or to resurrect an extinct species? Airing: 09/09/20

Through a series of discoveries beginning in the 1990s, scientists discovered CRISPR CAS-9. Found in microbial genomes as a natural defense against viruses, CRISPR sequences can be used to program cells to edit their own DNA, a revolutionary technology with the potential to change the course of human evolution.

The discovery has led to new approaches to treating genetic diseases. Almost overnight, it became theoretically possible to change the unchangeable: This technology could be used to cure cancer, sickle cell disease, muscular dystrophy, and other devastating previously incurable genetic diseases.

But it has also fueled a sharp debate over what constitutes a “normal” human being and whether we should ever seek to change who we are by altering our genomes—or those of our children.

“We made this film to help people wrap their heads around one of the most important scientific breakthroughs of our time and we’re thrilled that NOVA is bringing it to public television,” says “Human Nature” Producer and Director, Adam Bolt. “Everyone should have a chance to understand what CRISPR is and where it came from, so they can be part of deciding where this incredible technology will take us.”

Today, there seems to be no end to the difficult ethical questions raised by the technology. Where do we draw the line with genetic manipulation? Whose diseases get cured? What is a disability? Do parents have a right to choose the characteristics of their children? What are the long term consequences of manipulating the human genome, and changing forever the course of our evolution?

“Human Nature” engages the world’s leading geneticists and scientists to explore the vast implications of this relatively new scientific discovery, and the difficult questions it poses.

The film introduces David Sanchez, a young man who has sickle cell disease, and his family. David is one of the millions of people whose genetic disease scientists are already trying to cure using CRISPR CAS-9 gene editing. David’s family hopes that within his lifetime this sort of genetic intervention will be available to him.

Alongside David, “Human Nature” tells the story of CRISPR’s discovery, the spread of its use across the globe, and its current applications. Many of the scientists involved in the CRISPR revolution are featured in the film, including Jennifer Doudna, the UC Berkeley biologist who made one of the key discoveries of the CRISPR CAS-9 DNA editing process.

Other voices in the film include Nobel Prize-winning scientist David Baltimore, geneticist George Church, bioethicist Alta Charo, and many others.

“Human Nature” takes on the major ethical questions posed by the CRISPR revolution—watch as the world’s leading scientists, geneticists, and medical professionals, alongside real people suffering from genetic diseases, reckon with our role in human evolutionary history and the potential of CRISPR to change the world.

The documentary approaches this incredible story of scientific development through a uniquely human lens—and examines the moral quandary of gene editing. The documentary is an experiment in science storytelling, interweaving the macro- and micro-narratives in the ongoing story of DNA modification.

“Human Nature” is the product of a first-of-its-kind collaboration between scientists, journalists, and filmmakers to bring to the public a unique insight into perhaps the most significant scientific and medical discovery in our lifetimes.

Watch On Your Schedule:

This episode will be available for streaming simultaneously on all station-branded PBS platforms, including PBS.org and the PBS Video App, which is available on iOS, Android, Roku, Apple TV, Amazon Fire TV and Chromecast, for a limited time.

Extend your viewing window with KPBS Passport, video streaming for members supporting KPBS at $60 or more yearly, using your computer, smartphone, tablet, Roku, AppleTV, Amazon Fire or Chromecast. Learn how to activate your benefit now.

Join The Conversation:

NOVA is on Facebook, and you can follow @novapbs on Twitter. #NOVAnext

Credits:

A NOVA production by the Wonder Collaborative for NOVA/WGBH Boston. Produced by Meredith DeSalazar and Sarah Goodwin. Produced and Directed by Adam Bolt. Written by Adam Bolt and Regina Sobel. Executive Producers are Elliot Kirschner, Dan Rather and Greg Bousted. Executive Producers for NOVA are Julia Cort and Chris Schmidt. NOVA is a production of WGBH Boston. ©2019_iBiology Inc. and WGBH Educational Foundation. All Rights Reserved.

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