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Lenacapavir has the potential to end the HIV epidemic, researchers say. The Trump administration says backing this kind of effort will be a model for how it does global health work in the future.

A Christmas Eve Powerball drawing could add new meaning to holiday cheer as millions of players hope to cash in on the $1.7 billion prize.

The city is trying to turn that around. But so far, it’s not working.

FilmOut San Diego is one of the longest-running film festivals in Southern California and the only LGBTQ film festival in the San Diego area. Our festival and screenings are well-respected in the film community and often have World and U.S. premieres. Visit: https://filmoutsandiego.com/ FilmOut San Diego on Instagram and Facebook

In-person, free event! To register and for more information, visit: https://obosdjamesmcbrideevent.eventbrite.com Please join KPBS and our community partners for a special in-person event with James McBride, author of our 2025 One Book, One San Diego adult selection, "Deacon King Kong." The Belly Up venue is exclusively for individuals who are 21 years of age or older. Please remember to bring a valid ID with you as the venue strictly enforces age verification for entry. Event Schedule: Doors Open: 6:45 p.m. Author Talk with Q&A: 7:15 p.m. - 8:15 p.m. Book Signing*: 8:15 p.m. - 8:45 p.m. *Book signing will be first come, first served as time allows. The Belly Up is proud to be handicap accessible, ensuring that all our patrons can enjoy our shows comfortably. If you require accommodations, please email jmdean@kpbs.org in advance of the event. One Book One San Diego is funded by the Linden Root Dickinson Foundation, the Seth Sprague Educational and Charitable Foundation, the Frieda Berlinski Foundation, the Payne Family Foundation, Kaiser Permanente, the City of San Diego, and Lloyd Pest Control. A big thank you to the Belly Up for hosting this year's One Book, One San Diego Author Event!

This fall at least 200,000 California students are expected to enroll in transitional kindergarten, which serves as a bridge between preschool and kindergarten.

Join The Forum Carlsbad for the Spring Art & Wine Walk on Saturday, April 5 from 3 p.m. - 6 p.m. This highly anticipated annual event invites guests to explore an inspiring showcase of art while enjoying wine tastings, live music, and a lively community atmosphere. Visitors can stroll the center during this free event to discover an eclectic mix of artwork—from paintings and ceramics to photography and mixed media—displayed in participating shops and restaurants. The Wine Garden near YETI will feature a thoughtfully curated wine tasting presented by Jimbo’s, accompanied by a handcrafted charcuterie grazing table from Mirabelle Charcuterie. Guests can also enjoy a cupcake bar hosted by Jimbo’s and indulge in frozen treats from McConnell’s Fine Ice Creams, all while enjoying live acoustic music by the talented Freddie Walton. The Forum Carlsbad on Instagram

Discover the vibrant arts scene at San Diego International Airport’s new Terminal 1, where travelers are immersed in a dynamic collection of public art and exhibitions showcasing the region’s local culture. From eye-catching sculptures like the giant pink jellyfish to interactive LED installations, Terminal 1 offers a unique and inspiring experience for visitors of all ages. Whether you’re arriving, departing, or simply exploring, be sure to check the calendar for special events, musical performances, and rotating exhibits that celebrate San Diego’s rich artistic heritage and creative community. Available to view 24 hours / day The New T1 Parking Plaza More at arts.san.org

The Gaslamp Museum at the Davis-Horton House invites visitors to explore the rich history of early downtown San Diego and discover the vibrant Gaslamp Quarter. As the oldest standing structure in downtown, the museum offers a unique window into the city’s past, from Victorian-era life to the stories of pioneers who shaped our community. Through engaging exhibits, guided tours, and programs, the museum brings history to life for locals, students, and visitors alike, preserving the character and culture of one of San Diego’s most iconic neighborhoods. Museum Hours: Thursday - Saturday from 10 a.m. – 4 p.m. Visit: tours.gaslampfoundation.org Gaslamp Museum at the Davis-Horton House on Facebook / Instagram

After Republicans lost big in Tuesday's elections, adding pressure to end the government shutdown, President Trump pushed changes to Senate rules to bypass the need for Democratic-votes.