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It appears to be all over for the Borders bookselling chain. Almost 11,000 employees will lose their jobs when the company closes its remaining 400 stores by the end of September. Though the two chains pioneered the book megastore business 40 years ago, Borders made some critical missteps over the years that cost it the business.

For decades, the U.S. sought stability in the Middle East. But the upheavals of the past year have left the region in flux, and the U.S. is trying to define a new policy for dealing with changes that are still playing out.

In Marisha Pessl's dark, cinematic new novel Night Film, a disgraced journalist takes on a mysterious filmmaker who seems to be a hybrid of Roman Polanski and Dario Argento. It's an over-the-top summer mystery, full of twisty plotting and cinematic imagery.

ANALYSIS: The caucuses are largely an excuse for candidates to try to charm voters for the cameras, and for journalists to harass candidates, voters and the journalists' own audiences.

Why are those netbook computers so popular right now? What's the newest 3G phone on the market? And, are consumers spending less on tech gadgets this holiday season? We speak to Brian Cooley from CNET about this year's most innovative, and sought-after tech gadgets.

UCSD Medical School is looking for a few good brains. Over the next decade, the school's Brain Observatory is hoping 1,000 San Diegans will donate their brains for scientific research.

Embattled President Hosni Mubarak's regime set up a committee Tuesday to recommend constitutional changes that would relax presidential eligibility rules and impose term limits.

For decades, the U.S. sought stability in the Middle East. But the upheavals of the past year have left the region in flux, and the U.S. is trying to define a new policy for dealing with changes that are still playing out.

The story of Apple founder and CEO Steve Jobs taking another medical leave as he battles with cancer has been a big media story this week. It’s a led to some extravagant claims by reporters and their sources about Jobs’ demigod status.

Google, Yahoo, Cisco and Microsoft will be on the Capitol Hill hot seat for their role in helping the Chinese government monitor and censor the Internet. The House International Relations subcommittee on global human rights will hold hearings Wednesday about high-tech firms doing business in China.