We find the young American couple, Roy (Woody Harrelson) and Jessie (Emily Mortimer) at a banquet celebrating the work of a religious group in China. Roy was one of the Americans participating and Jessie took photos of the children whose lives have benefited from the group's efforts. Rather than fly home, the couple opts for an adventure. They decide to take the long way home on the legendary Trans-Siberian Express train from Beijing to Moscow. Their first encounter with a passenger on the train leads to a warning about not messing with the Russian police. That sets the stage for what's to come.