UCSD School Of Medicine Researchers Begin COVID-19 Ultrasound Spleen Study
Wednesday, May 12, 2021
Credit: UC San Diego Health
Researchers at UC San Diego School of Medicine have began a pilot clinical trial to test the efficacy of using ultrasound to stimulate the spleen and reduce COVID-19-related inflammation, decreasing the length of hospital stays, it was announced Wednesday.
"It's a pilot study to evaluate whether ultrasound stimulation focused on the spleen can reduce inflammatory biomarkers in hospital patients infected with SARS-CoV-2," said Dr. Imanuel Lerman, associate professor of anesthesiology at the school and an affiliate of Qualcomm Institute at UCSD, where his lab is based. "This will allow us to determine whether treating patients this way can really affect clinical outcomes in COVID-19 infections."
The two- to three-month study will recruit 40 patients with severe COVID-19 symptoms, all admitted to Jacobs Medical Center at UCSD Health. Half will be given ultrasound treatment daily for up to seven days, in addition to receiving anti-inflammatory drugs, such as remdesivir and dexamethasone, which are currently part of standard medical care. The other half — the control group — will receive standard medical care.
"We will be watching to see how quickly the ultrasound patients can be discharged from the hospital compared to the control group," Lerman said. "While we are planning to do the ultrasound treatments up to seven days, we're hoping that ultrasound stimulation of the spleen can get them home even sooner and also prevent patients from experiencing more severe symptoms while in the hospital."
In earlier rodent studies, stimulating the spleen with a non-invasive ultrasound device was shown to reduce inflammation, Lerman said. Researchers also demonstrated the anti-inflammatory value of spleen stimulation in healthy human subjects and in human patients with rheumatoid arthritis.
Both RA and COVID-19 patients can suffer from a hyperinflammatory response driven by over-production of cytokines — proteins that signal and spur an inflammatory immune response. The resulting "cytokine storm" in COVID- 19 patients can lead to acute respiratory distress syndrome, which can be fatal.
In a July 2020 study on medRXiv, an online site that posts papers that have not yet undergone peer review, General Electric Research and University of Minnesota scientists described the effects of splenic stimulation in RA and healthy patients, and its potential in COVID-19 patients:
"Non-invasive ultrasound activation of the splenic neuroimmune pathway may provide an alternative method to combat the cytokine storm without compromising the adaptive immune response in COVID-19 patients, ultimately reducing the high mortality and morbidity rates confronting this worldwide pandemic that currently has limited treatment options," the paper reads.
Prior studies have also shown that electrical stimulation of the vagus nerve, which runs from the brain to the gut, using a cervical implant, reduces inflammation. Stimulating the spleen may activate the same anti- inflammatory pathways, UCSD researchers said.
The clinical trial will use an investigational device developed by SecondWave Systems. Strategically placed on patients' skin, the device generates low-intensity, focused ultrasound waves targeting the spleen. Treatment occurs daily for approximately 18 minutes for up to seven days.
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