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The North County Transit District took time to deliberate Tuesday morning before ending the mask policy.
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As COVID-19 cases decrease, antiviral treatments to prevent hospitalization and death are more readily available.
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The mask-wearing requirement had been initially imposed in early 2021, shortly after President Biden took office.
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A federal judge in Florida has voided the national mask mandate covering airplanes and other public transportation as exceeding the authority of U.S. health officials.
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The county's cumulative totals increased to 754,544 infections and 5,230 deaths with Friday's data.
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The spike is primarily attributed to a new highly transmissible omicron variant.
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A new study published in the New England Journal of Medicine Wednesday evaluates the effectiveness of a second COVID-19 vaccine booster for people 60 and older.
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County officials Wednesday reported its second pediatric death from COVID-19, a 15-year-old girl who died Feb. 3.
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The Biden administration will continue to require travelers to wear masks on planes and other forms of public transport.
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The order was set to expire April 18, but the Centers for Disease Control and Prevention is set to extend the order by two weeks.
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