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Dr. Kevin O'Connor, the White House physician, reports that President Joe Biden has "residual nasal congestion and minimal hoarseness" after four full days of Paxlovid treatment.
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Manchin said he was experiencing mild symptoms, while Murkowski said she was experiencing flu-like symptoms.
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Hospitalizations are up significantly, but the cases are less severe and fewer people are in intensive care units or on ventilators, officials say.
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The Health and Human Services Agency reported 2,007 new infections and 10 deaths Thursday night, increasing the county's cumulative totals to 870,079 cases and 5,387 deaths.
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It's a common dilemma in this summer of surging travel and surging COVID. If one member of a vacation party comes down with the virus, what steps can be taken to reduce the risk to others?
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The president will isolate through Tuesday, and if he tests negative, at that point he could resume a normal schedule on Wednesday. He has continued to work since testing positive on Thursday.
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President Biden had a slightly elevated temperature last night but his physician says that "his symptoms have improved" as he receives treatment after testing positive for COVID-19 on Thursday.
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Paxlovid has been highly effective at reducing the risks of hospitalization and death, but some patients report a "Paxlovid rebound," in which the disease returns.
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The 79-year-old president "will isolate at the White House and will continue to carry out all of his duties fully during that time," a White House statement said.
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"Willing it away isn't going to work," physician scientist Dr. Eric Topol said of the BA.5 coronavirus variant.
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