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The sedative xylazine is starting to permeate illegal opioids and cocaine. It does not respond to naloxone, an overdose reversal medication, and may be to blame for grisly injuries and infections.

As the investigation into Saturday's fatal shooting in Paradise Hills continues, San Diego olice officials say it appears to be a case of "domestic violence murder-suicide."

Friday, Feb. 3, 2023 at 10 p.m. on KPBS 2 / not available on demand. ACL presents selected performances from the 20th annual Americana Awards & Honors, recorded live in Nashville. Performers include Brandi Carlile, the Mavericks, Jason Isbell, Allison Russell, Charley Crockett, Amethyst Kiah and the Highwomen, plus a tribute to Nanci Griffith from Joe Henry and Aoife O'Donovan.

San Diego Mayor Todd Gloria says he’s proposing the largest infrastructure investment in city history.

There's no law against a couple of shortcuts when you're catching up on a beloved TV show. And even if you were, Better Call Saul's Jimmy McGill would tell you to take them anyway.

The jury concluded that former certified nursing assistant Matthew Fluckiger sexually assaulted one woman twice in one hour.

Residents of St. Mary's in southwestern Alaska are donating food to firefighters and helping clear brush as the region's largest wildfire looms just a few miles from town.

Beyoncé won four prizes to become the artist with the most Grammys in history, but the night's biggest prizes went to Harry Styles, Lizzo and Bonnie Raitt.

As health officials sound the alarm about the pandemic's impact on children's mental health, music, drama and other art classes are helping kids adjust to being in-person again.

San Diego Mayor Todd Gloria delivers his first State Of The City address on Wednesday. Meanwhile, San Diego congressional representatives make their case for or against impeachment on Capitol hill - mostly for. Plus, delivery drivers at supermarkets are already seeing the effects of Prop 22.