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  • Pixar's new 3-D animated film Up opens this weekend. We'll hear from the director and producer, and talk with KPBS film critic Beth Accomando about how Up breaks different ground in 3-D animation.
  • Before there was Bernie Madoff, there was Ivar Kreuger, the man John Kenneth Galbraith called the Leonardo of scammers. When Kreuger, an extremely successful and much-admired businessman during the 1920s, killed himself in 1932, investors discovered that his financial empire, based in the manufacture of matches, was made of sand, built out of complex financial instruments that are the forerunners of today's derivatives.
  • Americans Andrew Z. Fire and Craig C. Mello win the Nobel Prize in Physiology or Medicine for discovering "RNA interference," a way organisms turn off individual genes. The discovery is considered by many scientists to be a breakthrough in modern biology.
  • Device Gallery moved to a new space in Barrio Logan and to celebrate they opened a show of moving sculpture. It Moved! features kinetic work from six regional and national artists.
  • In dramatic, back-to-back speeches, the president repudiated the Bush administration for choosing "expedience" over the rule of law. The former VP, meanwhile, warned that Obama's efforts to find "middle ground" would leave the country exposed to attack.
  • The partisan divide over how to secure the nation's safety — and what was done in America's name after the attacks of Sept. 11, 2001 — intensified Thursday with dramatic, back-to-back televised speeches by President Obama and former Vice President Dick Cheney.
  • Indie Director Jim Jarmusch Tests the Limits
  • The number of assassinations in Afghanistan is growing, particularly in Kandahar province, where Taliban militants are strong and well-organized. Dozens of politicians, government employees, activists and Muslim clerics have been targeted. The threats have halted much government and social work in Kandahar, officials say.
  • Like all strains of influenza, the swine flu is expected to die down as warm weather sets in. But that doesn't mean it'll be gone for good. KPBS Reporter Tom Fudge has more.
  • Spunky animated film battles Wolverine at the box office this weekend
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