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Scientists in Geneva celebrated early Tuesday as the Large Hadron Collider started making subatomic particles collide head-on at record-breaking energies. Scientists hope that the massive particle accelerator will help answer some of the big questions of the universe.

Endeavour, the baby of NASA's fleet, roared off the launchpad at Florida's Kennedy Space Center for its final mission in 19 years of service. Arizona Rep. Gabrielle Giffords, the wife of mission commander Mark Kelly, was among the tens of thousands who gathered to watch.

Susan Isaacs' latest novel revolves around Gloria Garrison, a 79-year-old CEO with a multimillion-dollar makeover business. Isaacs says her female characters don't need to be likable, but they should "fight for something beyond themselves."

By 2020 an estimated 4 million licensed California drivers will be over the age of 65. A team of experts from UCSD are working on a program to identify and assist older drivers who may be at risk for a crash due to age-related health problems. We'll hear details of the driver screening and find out simple things seniors can do to improve their ability to drive safely.

Airs Wednesday, September 7, 2011 at 10 p.m. on KPBS TV

Among the candidates President Obama may nominate for the next defense secretary is Michele Flournoy, formerly the highest-ranking woman in the Pentagon.

Tinker, Tintin, Silent Stars and Spies

Pope Benedict XVI said Monday he lacks the strength to fulfill his duties and on Feb. 28 will become the first pontiff in 600 years to resign.

A 1,000-year-old statue, a vine-and-moss-covered temple complex and a country's turbulent history lie at the heart of a legal battle pitting the Cambodian government against Sotheby's auction house. Officials say the statue was looted from an ancient Khmer temple; Sotheby's says that's not provable.

The La Jolla Playhouse is staging a world premiere musical about the life of Charlie Chaplin. "Limelight" named after one of Chaplin's late films, focuses on the personal life of the film legend and includes a book written by the Tony Award winning writer of "Hairspray" and "The Producers." We'll talk with the musical's creative team.