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Sporting events and live theater announced cancellations amid major increases in new coronavirus cases, in large part because of the omicron variant.

Players are benched after testing positive, games are canceled or postponed and leagues and players' unions are scrambling to figure out how to move forward under a cloud of uncertainty.

The virus is the enemy, NIH Director Francis Collins said. "It's not the other people in the other political party." Omicron, which could soon become the dominant strain, is extremely infectious.

The highly transmissible variant has again upended life in the U.S., as officials warn of a coming spike in cases and people race to get booster shots and coronavirus tests during the winter holidays.

Collins is retiring after 12 years of leading the federal health agency. He parts with a warning about the dangers of yielding to pandemic fatigue. "The virus is not tired of us," he says.

From India to Israel to white-tailed deer in Iowa harboring the coronavirus, our top COVID stories of the year reveal the ever-changing nature of the world's health crisis.

Your college kid just got home and may be a bit jaded about COVID. But your coming holiday visit could be a real risk to grandparents. Here's how one mom is getting through to her sons about safety.

NPR's Mary Louise Kelly speaks with Dr. Ashish Jha, dean of Brown University School of Public Health, about safely navigating the holidays amid rising COVID case numbers.

San Diego County public health officials reported 1,032 new COVID-19 infections and seven additional deaths associated with the virus Friday, increasing the region's cumulative totals to 397,374 cases and 4,406 deaths since the pandemic began.

Researchers in South Africa have found that people infected with omicron, on average, are less likely to end up in the hospital. But the variant may act differently here in the U.S.