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Thursday's data increase the county's cumulative totals to 748,722 infections and 5,150 deaths since the pandemic began.
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The San Diego County Health and Human Services Agency reported 304 new COVID-19 infections and three additional deaths.
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Though findings are preliminary, many studies suggest that vaccinated people have good protection against the condition, although just how much is still up for debate.
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The city of San Diego announced a vaccine mandate for employees last year and this week hundreds of city employees are having exemptions granted.
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Monday's data follows case counts of 223 Sunday and 335 Saturday.
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Senior administration officials say Congress should provide the $22.5 billion President Joe Biden wants for continuing the battle against COVID-19 without cutting other programs to pay for it.
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Friday's data increased the county's cumulative number of cases to 747,174. No new deaths were reported Friday and that number remains 5,138.
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Thursday's data increase the county's cumulative totals to 746,533 cases and 5,138 deaths.
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Wednesday's data increases the county's cumulative totals to 745,684 cases and 5,133 deaths.
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KPBS Midday EditionDespite the widespread abandonment of COVID-19 safety protocols, signs are emerging that the United States will soon experience another wave of the virus.
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