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Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

Hundreds of protesters filled the streets outside the Pacific Amphitheater, where Donald Trump spoke as his presidential campaign gets rolling ahead of California's June primary.

For centuries, German law has stipulated that beer can only be made from four ingredients. But as Germany embraces craft beer, some believe the law impedes good brewing.

Whether your pet is a dog, cat, chicken or even an emu, teams are working to rescue animals from a fire burning in east San Diego County.

Finding homeless students is a challenge, as are resources and red tape. The new federal education law includes new mandates and some extra money to assist districts in helping more students.

Voters' minds are stubborn, and politicians habitually spout falsehoods. That doesn't mean fact-checking is a failure, though.

Thousands of residents of the Dominican Republic — many of Haitian descent — have been stripped of citizenship. Facing deportation, they've moved into camps. Now they're living in limbo.

General Motors has recalled 29 million autos in the U.S. so far this year. Dealers replacing the faulty parts aren't just fixing cars. They're repairing customers' relationships with the automaker.

Circus Collective of San Diego delivers "shock and awe" at Lyceum Space

The event is called National Night Out, and communities across the country will participate in the annual event Tuesday. Here in San Diego, it will take place at three mid-city locations.