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Supporters of Prop. 19 say that Mexican drug cartels will take a major financial hit if marijuana is legalized in California. A recent study by the Rand Corporation calls into question some of the figures that are being cited by Prop. 19 proponents. So, what kind of impact could Prop. 19 have on the cartels, and drug trafficking in the state?

What are San Diego scientists doing to find cures for some of the world's rarest diseases? We speak to KPBS Reporter Tom Fudge about the local efforts taking place at the Sanford Burnham Institute to find treatments and cures for "orphan" diseases.

The Scripps Institution of Oceanography research vessel Melville returned to San Diego after a two-and-one-half year expedition. Nearly 50 research projects in the western Pacific Ocean were complete

This is not opera as we know it. French composer Pascal Dusapin's chamber opera "To Be Sung" combines new music with a Gertrude Stein text. The graduate students at UCSD's Department of Music perform an ambitious production of "To Be Sung" in the Conrad Prebys Concert Hall this week. We'll talk with the director, soprano Susan Narucki and members of the creative team.

Just in time for Holiday toy shopping, we get a new look at how gender stereotypes can actually hinder a child's development. We'll speak with the author of PINK BRAIN/BLUE BRAIN about why girls need more Legos and boys need more time away from the computer.

Mayor Jerry Sanders and other city leaders are pushing for a $750 million expansion of the San Diego Convention Center, but how will they pay for it? We discuss how Proposition 26 and uncertain redevelopment revenue could affect the proposal.

Duplicity is a strange project from Tony Gilroy who's probably best known for adapting the Bourne books to film and more recently for writing a directing…

Where is climate change currently happening on Earth, and what's causing those changes to occur? We speak to a physicist from the Jet Propulsion Laboratory about where major climate changes are taking place, and how climate modeling helps to predict future changes in our atmosphere.

Isabelle, 9, was born with a rare genetic disorder that, among other things, means she is biologically incapable of not trusting people. Her pathological trust of everyone has made for some serious challenges in raising her, but Isabelle's parents say there are also rewards to a child with boundless love and trust.

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