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Of the 109 people currently listed as missing in South Dakota, 77 of them are indigenous. The state's legislature passed a bill this week to address the alarming crisis on and off reservations.

The lab has access to a high-security facility that Pfizer needed to prove its COVID-19 vaccine was working. Now the scientists there are testing the vaccine's effectiveness against viral variants.

An investigation by political appointees into the Voice of America's White House bureau chief for anti-Trump bias is the latest act that may break federal laws promising its journalistic independence.

The unemployment rate in San Diego County increased to 7% in June, up from a revised 6.3% in May but still well below the year-ago estimate of 13.5% — according to figures released Friday by the state Employment Development Department.

Thick smoke that held down winds and temperatures began to clear Sunday from the scenic forestlands of Northern California as firefighters battling the largest single wildfire in state history braced for a return of fire-friendly weather.

U.S. Education Secretary Miguel Cardona has tried to balance optimism around safe, in-person learning with political pugilism aimed at officials who are making it hard for schools to require masks.

The Centers for Disease Control and Prevention shifted its stance this week on the need to wear masks if you're vaccinated. What's that mean for kids? For travel? For work? Experts weigh in.

Haitian migrants camped on the Mexican side of the U.S. border are debating making the crossing north to face possible deportation to Haiti — or release into the U.S. for immigration hearings.

Court papers filed by the Justice Department allege that a member of the Oath Keepers coordinated with the Proud Boys and a far-right, self-styled militia to form an "alliance" on Jan. 6.

Empire of Pain author Patrick Radden Keefe says the Sackler family has "thrown a lot of energy" into trying to thwart his reporting about the family's involvement in the opioid crisis.