Fixing the misfolded proteins that cause dementia and heart failure - Front Row lecture with Jeffery Kelly, PhD Description: All proteins have a correct way of “folding” themselves into their three-dimensional structures. When this folding process goes awry, including processes leading to protein misassembly, a number of devastating diseases can result. In this free Front Row lecture, Scripps Research professor Jeffery Kelly will share how he is developing novel therapeutic strategies to target these protein misfolding diseases, which lead to deterioration of the heart and brain. His multi-disciplinary research has already led to the development of an FDA-approved drug available in the pharmacy called tafamidis (Vyndaqel® and Vyndamax®): a medicine that slows the progression of the neurodegenerative disease familial amyloid polyneuropathy and the degenerative heart disease called TTR cardiomyopathy. ABOUT SCRIPPS RESEARCH Scripps Research is an independent, nonprofit biomedical institute based in La Jolla, California, and ranked one of the most influential in the world for its impact on innovation. The Front Row lecture series, now in its seventh season, offers an exclusive glimpse into groundbreaking scientific discoveries in action. In 2024 we celebrate a century of turning vision into pioneering impact. Reserve your seat today and learn how our scientists remain at the forefront of advancing the future of science and medicine. We hope you’ll join us—in the front row—for the next century of Science Changing Life. Scripps Research on Facebook / Instagram
