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Hillary Clinton told reporters at the State Department that with Barack Obama now in the White House, Iran has a "clear opportunity" to engage meaningfully. She also said she had sensed relief among foreign diplomats with the change of administration.

Richard Holbrooke has been named special representative to Pakistan and Afghanistan, and George Mitchell has been picked to be special envoy for Middle East affairs. Rami Khouri, editor at large of the Daily Star newspaper in Beirut, Lebanon, and director for the Fares Institute of Public Policy and International Affairs, weighs in.

At the State Department, there's a new sheriff in town. With Secretary of State Hillary Clinton's arrival and upbeat speech to the staff about working together to bring the best of America to the world, has she also brought a new mood to the nation's diplomatic corps?

Hillary Clinton has taken charge at the U.S. State Department. The secretary of State named George Mitchell to be a special envoy to the Middle East and Richard Holbrooke to be a representative on Afghanistan and Pakistan.

On Day 2 of his presidency, Barack Obama continued to unravel the tapestry of policies woven by former President Bush over the past eight years. Shuttering the detention facility is intended to show that U.S. foreign policy is changing, the president said.

More than 14,000 candidates are running in Iraq's provincial elections scheduled for the end of the month. It's the first time since 2005 that Iraqis are going to the polls. If the process isn't seen as legitimate, Iraq's fragile democracy could be threatened.

The inauguration of Barack Obama as the 44th president of the United States has brought a sense of hope and possibility. NPR reporters offer updates on the mood in Kenya, Iraq and elsewhere on Inauguration Day.

The Bush administration leaves behind a solid legacy in humanitarian aid and development, says Henrietta Fore, the outgoing director of U.S. foreign assistance and head of USAID. Her final days on the job are busy, dealing with crises in Gaza and Zimbabwe.

Secretary-General Ban Ki-moon, in Gaza to push for a cease-fire, said he was outraged by the attack on a U.N. relief agency. At least three people were wounded, and hundreds of pounds of food were destroyed.

Israel's offensive in the Gaza Strip enters its 18th day. Israeli ground forces are pushing slowly but steadily into the more densely populated areas of Gaza City. Talks about a cease-fire continue in Cairo, but it doesn't look as if they're making any progress.