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San Diego Researcher Helps Draft New Dietary Guidelines For Cancer Prevention

GUEST:

Dr. Gordon Saxe, UC San Diego Health Center

Transcript

Six new dietary guidelines for cancer prevention are out and they're more aggressive than previous prevention advice.

Dr. Gordon Saxe of UC San Diego Health System co-authored the new recommendations from the Physicians Committee for Responsible Medicine published in the Journal of the American College of Nutrition Monday.

The guidelines encourage people to limit alcohol, dairy products, red and processed meats and emphasize a diet high in soy products, fruits and vegetables.

The six dietary recommendations to reduce risk of several types of cancer are:

Limit or avoid dairy products to reduce the risk of prostate cancer

Findings: Consuming 35 grams of dairy protein each day — the equivalent of one and a half cups of cottage cheese — increases risk of prostate cancer by 32 percent. Drinking two glasses of milk each day increases risk of prostate cancer by 60 percent.

Note: Calcium supplements appear to have the same effect as milk intake. Men who supplement with more than 400 milligrams of calcium per day increase risk for fatal prostate cancer by 51 percent.

Limit or avoid alcohol to reduce the risk of cancers of the mouth, pharynx, larynx, esophagus, colon, rectum, and breast

Findings: One drink per week increases risk of mouth, pharynx, and larynx cancers by 24 percent. Two to three drinks per day increase risk of colorectal cancer by 21 percent.

Note: The alcohol itself (rather than additives) appears to be the cause of cancer, and all types of alcoholic beverages (wine, beer, and spirits) are problematic.

Avoid red and processed meats to reduce the risk of cancers of the colon and rectum

Findings: Each 50 gram daily serving of processed meat — equivalent to two slices of bacon or one sausage link — increases risk of colorectal cancer by 21 percent. Each 120 gram daily serving of red meat, equivalent to a small steak, increases risk of colorectal cancer by 28 percent.

Note: The heme iron, nitrites, heterocyclic amines, and overabundance of essential amino acids in red and processed meats are all believed to contribute to cancerous cell growth in the body.

Avoid grilled, fried, and broiled meats to reduce the risk of cancers of the colon, rectum, breast, prostate, kidney, and pancreas

Findings: Four types of heterocyclic amines (HCAs) are associated with cancer of the colon and rectum. HCAs form from creatine and amino acids in cooked skeletal muscle, increasing with higher cooking times and higher temperatures. When ingested, HCAs can disrupt DNA synthesis.

Note: In addition to the cancers listed above, HCAs are also associated, to a weaker extent, with cancers of the breast, prostate, kidney, and pancreas.

Consume soy products to reduce risk of breast cancer and to reduce the risk of recurrence and mortality for women previously treated for breast cancer

Findings: Evidence from Asian and Western countries shows that soy products are associated with reduced cancer risk. Chinese women who consume more than 11.3 grams of soy protein, equivalent to half a cup of cooked soybeans, each day during adolescence have a 43 percent reduced risk of premenopausal breast cancer, compared with women who consume 1.7 grams. Research in Shanghai shows that women with breast cancer who consume 11 grams of soy protein each day can reduce mortality and risk of recurrence by about 30 percent. U.S. populations show similar findings: the higher the isoflavone intake from soy products, the less risk of mortality and recurrence in women with breast cancer.

Note: When choosing soy products, opt for natural forms, such as edamame, tempeh, or organic tofu, as opposed to soy protein concentrates and isolates, common in powders and pills.

Emphasize fruits and vegetables to reduce risk of several common forms of cancer

Findings: Fruits and vegetables, especially leafy greens, help reduce overall cancer risk. A high intake of cruciferous vegetables, such as broccoli, kale, and cabbage, is associated with an 18 percent reduced risk of colorectal cancer and reduced risk of lung and stomach cancers. Women who consume the most carotenoid-rich vegetables, such as carrots and sweet potatoes, lower their risk of breast cancer by 19 percent. Overall, women who consume the highest quantities of any kind of fruit or vegetable reduce breast cancer risk by 11 percent. A high intake of tomato products has been shown to reduce risk of gastric cancer by 27 percent. Garlic and other allium vegetables, such as onions, significantly reduce risk for gastric cancer, while a Western diet (high amounts of meat and fat with minimal amounts of fruits and vegetables) doubles the risk.

Note: Some components in soybeans, green tea, turmeric, grapes, tomatoes, and other plant foods have the ability to regulate apoptosis (a natural process for destroying unhealthy cells), an important pathway for cancer prevention.

“There’s considerable benefit--and no harm—in loading up with plant-based foods,” notes study author Susan Levin, M.S., R.D., C.S.S.D., director of nutrition education for the Physicians Committee. “Large bodies of research show fruits, vegetables, and legumes offer a variety of protective properties, so why not move these foods to the center of our plates?”

The World Health Organization states that a significant percentage of cancers can be prevented by following a healthful diet, avoiding tobacco, leading an active lifestyle, and limiting alcohol intake.

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