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The Novo Nordisk diabetes medication was found to cause significant weight loss in users and has since become a blockbuster drug and very big business.

Written by Matt Cox Directed by Rhiannon McAfee Puffs is back! From the company that brought you the West Coast Premiere, and the Winner of the Broadway World San Diego Award for Best Professional Play. Don't miss this year's Puffs, Or: Seven Increasingly Eventful Years at a Certain School of Magic and Magic. For seven years a certain boy wizard went to a certain Wizard School and conquered evil. This, however, is not his story. This is the story of the Puffs... who just happened to be there too. A tale for anyone who has never been destined to save the world. Running Time: 1 hour 50 minutes Puffs contains language that may not be suitable for all ages... but then again, we don't tell you how to parent. Special Family Friendly Sunday Matinees for all your first years! Puffs is presented by special arrangement with Samuel French, Inc., a Concord Theatricals Company. Related links: Fenix Theatre Collaborative on Instagram Fenix Theatre Collaborative website

Comet C/2022 E3 was first spotted last year. Its path will bring it within 26 million miles of the Earth on Wednesday, allowing it to be visible to the naked eye for perhaps the last time ever.

City officials assured residents on Monday that the water was safe to drink throughout the day, but added that they are continuing to test the water supply.

The San Diego City Council Monday heard the presentation of Mayor Todd Gloria's proposed Fiscal Year 2024 $5.12 billion budget, with the body's members focused on equity in various departments and addressing homelessness.

The friendship shared by Julien Baker, Phoebe Bridgers and Lucy Dacus isn't just the backdrop for their album as boygenius: It's the subject of many of these songs, built into their very structures.

Young tech nerds in Seattle are trying to preserve the mysterious machines — many of them almost lost forever — that made America's landline telephone system work before the age of computers.

After much research and consideration, the Pantone Color Institute has revealed the color of the year for 2023. It calls Viva Magenta "an unconventional shade for an unconventional time."

Picasso was the first rock-star artist—a ferocious pacifist, obsessive art maker, flamboyantly opinionated philosopher, and self-proclaimed clown—who relished his passionate views about love, death, war, beauty, eternity, and creativity. Herbert Siguenza creates a joyful and mesmerizing portrait of the maestro as he dances, sculpts, shares secrets, clowns, draws and impersonates a matador while extensively quoting the father of modern art. With a skill that will amaze you, the actor draws and paints in real time during his performance! Having wowed audiences in San Diego, L.A., the Bay Area, Houston, Denver, and more, Siguenza’s one-man tour de force returns for a limited time on film, stronger than a bull in a china shop! Date | Available for streaming until Sunday, February 6 at midnight Location | Online Get tickets here! Access to the play goes from $15 to $250. This show is brought to you by San Diego Repertory Theatre. For more information, please visit sdrep.org/show-detail.php?id=634 or call (619) 544-1000.

The 4-decades long effort to create an AIDS vaccine suffered a blow with news that a vaccine in a late stage trial was discontinued because results showed it to be ineffective. What are the obstacles?