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For some people, a rare genetic mutation makes dementia inescapable. Three sisters have decided to confront fate with a genetic test and have joined a research project on possible treatments.

Dr. Demetre Daskalakis is steering the U.S. monkeypox response. A month into the job, he sees signs of success, but there's still more to be done.

The national average price of gasoline has fallen below $4 a gallon. These are four key factors that could determine what happens next with prices at the pump.

The Windermere Homes & Estates offices are set to host a blood drive on Oct. 12, 2021 from 10 a.m. until 3 p.m. at their Rancho Bernardo, Escondido and Carlsbad locations. The blood drive will be in conjunction with the San Diego Blood Bank (SDBB) and will follow state-wide COVID-19 guidelines which include mask requirements and social distancing. Donors will need to bring a form of ID to the event. The event will be accepting both walk-ins and appointments made on the San Diego Blood Bank website, http://sandiegobloodbank.org/donate. Each location will be able to take care of an estimated 38-40 spots. Unfortunately, the SDBB currently has a three-day or less supply of most blood types on the shelves. A seven- to ten-day supply is considered ample. “Every year since 1984, the Windermere offices have an annual tradition of closing the business for the day during the summer and fall in order to participate in Community Service Day,” states Windermere founder Rich Johnson. “We knew how hard our local community was hit by the pandemic over the last year, especially the outcry from our local media stations, friends and family about the shortage for blood so when it came time for this year’s Community Service Day, we knew exactly where to turn: the San Diego Blood Bank. We hope with our efforts, we can help supply SDBB’s urgent calls for donations.” For more information please visit: https://www.mysdbb.org/donor/schedules/zip

Suit up in your dirndl and lederhosen and 'prost' to the new season at One Paseo’s inaugural Oktoberfest celebration. Guests can expect beer tents, German-inspired picnic plates by crafted The Butchery, German chocolate cupcakes from Susie Cakes, traditional lawn games including axe throwing, the crowning of Mr. and Mrs. Oktoberfest, music, and more! In addition to the food and fun, tickets include 4 oz. pours from the event’s beverage partners, including: • Embolden (New Motion Beer and Hard Sparkling Tea) • Sundowner Spirits • Jetway • Juneshine • Fort Point • De La Calle (Non-alcoholic Tepache) • Harland Brewing CompanyThe 21+ event will take place on Saturday, October 2 from 2 p.m. to 6 p.m., and will be held on One Paseo’s lawn, located behind Harland Brewing. Get tickets here! Tickets for the event are $20 For more information, please visit One Paeo's site or call (858) 523-2298.

A wrongful murder conviction forced Woodfox to spend 43 years and 10 months in solitary confinement at Louisiana's Angola Prison. He has died at the age of 75.

There are only a few clinics in the country that provide abortions later in pregnancy. One in New Mexico has recently seen a significant increase in patients and is bracing for more.

U.S. officials announced Tuesday that the two states, which rely on water from the Colorado River, will face more water cuts as they endure extreme drought.

We asked people who immigrated to the United States what the day meant to them — and how their feelings about the holiday have changed since they first arrived.

From San Diego Weekend Arts Events: This is your last chance to catch City Ballet of San Diego until they perform the Nutcracker in late December. "On the Move" is a collection of works that debuted this summer to multiple sold-out audiences — but this weekend there's just one chance to see them live, this time on the Baker-Baum Concert Hall stage at The Conrad in La Jolla. Two of the works, "Unbroken," and "Within the Hourglass Desert," are new pieces premiered this summer by company choreographer Geoff Gonzalez, both set to compositions by influential American composer Philip Glass. —Julia Dixon Evans, KPBS Details: Saturday, Oct. 23 at 8 p.m. The Conrad, 7600 Fay Ave., La Jolla. $39-59. From the organizers: In July, City Ballet returned to the live stage with two sold-out performances of ON THE MOVE. For one night only, City Ballet reprises these two world-premiere ballets by Resident Choreographer Geoff Gonzalez at the Conrad Prebys Performing Arts Center in La Jolla. Unbroken: A testament to the resiliency of humankind. Within The Hourglass Desert: A piece highlighting the finite beauty of time. Clare de Lune: This ballet reflects Debussy’s use of harmony and texture in a way that recalls the light and color of French Impressionist painting. Date/Location: Oct. 23, 2021 @8:00 p.m. The Conrad Presbys Performing Arts Center Price: $42-$62/person For more information on this event please visit: City Ballet of San Diego's: On the Move