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The al-Qaida leader's message to President Obama this week shows he's still in the fight. But intelligence officials say the combination of Pakistan's military push, the U.S. troop increase in Afghanistan and stepped-up drone strikes is putting pressure on the terrorist organization.

On the eve of President Obama's speech in Cairo on Thursday, a recording, believed to be of Osama bin Laden, also made headlines. The message is the latest sign that the al-Qaida leader is alive, up on current events and communicating with the outside world. But a number of factors may now be combining to make bin Laden's safe haven in Pakistan less so.

Calling across a chasm that has opened wider in the years following the Sept. 11 attacks, President Obama spoke Thursday about U.S. relations with the Muslim world. He hopes to "start a dialogue" to repair tattered U.S. ties with the globe's 1.5 billion followers of Islam.

Grass-roots activism has grown in China in recent years. But the demands of one group continue to fall on deaf ears: the Tiananmen Mothers. The parents of children who were killed 20 years ago in the crackdown on democracy protests want a full public accounting of the incident.

La Jolla Playhouse stages celebrated playwright Terrence McNally's latest drama Unusual Acts of Devotion. In the play, McNally charts damaged souls and damaged cities, loves lost and recovered, and the joys of simple but enduring acts of devotion.

Cancer is the leading cause of death in San Diego County. But a cancer diagnosis is not necessarily a death sentence. On the eve of National Cancer Survivor's Day, which is June 7, we'll explore the latest in cancer rates and treatments, and talk with cancer survivors.

The two journalists on trial in North Korea are freelancers for Current TV — the brainchild of former Vice President Al Gore. Current is a hybrid: a TV station and Web site that offers user-generated programming targeted at the audience of 18 to 34 year olds. The idea is to democratize TV production. But the company has come under fire for keeping quiet on two of its journalists being held in North Korea.

The city of San Diego is in the early stages of creating a year round homeless shelter downtown. All of the people and organizations involved agree something needs to be done about the hundreds of homeless people living on the streets. But what to do and how are unresolved questions.

Pledging "to seek a new beginning between the United States and Muslims," President Obama reached out to the world's 1.5 billion followers of Islam Thursday, addressing an appreciative crowd at Cairo University.

The state plans to borrow $36 million from the city of San Diego and another $70 million from the county to help close its $24 billion budget deficit, it was announced today.