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On Thursday, President Obama makes a major address on the uprisings sweeping the Middle East and North Africa and what those events mean for the U.S. His comments will likely be compared to his speech in Cairo in June 2009, where he went to "seek a new beginning" in the region and the Muslim world.

Indonesia is struggling to deliver aid to people who survived an earthquake that killed more than 5,400 people over the weekend. At least 22 countries have pledged to help relief efforts. At the same time, Indonesian authorities continue to watch for the eruption of an active volcano in the area. And six more human cases of bird flu have been reported.

A bloody gun fight in Tijuana early Saturday morning was one of the deadliest incidents in years along the U.S.-Mexico border. Fifteen people were killed and nine injured. It's the latest battle in a

Simon Wiesenthal, who died Tuesday at age 96, survived the Holocaust and devoted his life to finding Nazi fugitives and bringing them to justice. He was best known for helping to track down Adolph Eichmann, a key architect of Hitler's genocide.

There is no cure for advanced lung cancer. Patients usually die within a year of being diagnosed. But there could be some hope on the horizon. A San Diego biotech company has developed a vaccine it ho

Israeli Prime Minister Ariel Sharon survives a no-confidence vote Monday, the same day he sought to form a unity government with opposition leader Shimon Peres. Sharon's coalition government barely survived the no-confidence attempt, which fell just six votes short in the Israeli parliament. Hear NPR's Peter Kenyon.

A former Secret Service officer who helped thwart the attempted assassination of President Harry Truman has died. Floyd Boring, 92, changed the course of history when he and White House police officers took on two armed men during a shootout near Blair House, where Truman was staying during White House renovations.

The city of San Diego gained national notoriety with its billion dollar pension deficit. KPBS reporter Alison St John surveyed the other 17 cities in the county, and found many cities are paying more of their annual budgets towards pensions than San Diego.

Why is the “San Diego Union-Tribune” reducing its news staff? The newspaper recently sent out a memo to employees announcing a "Voluntary Separation Program" as a way to cut costs.The story of what'

Call them what you will - unauthorized , illegal, or undocumented - the three million immigrants in California who either entered the U.S. illegally or overstayed their visas have an impact on the state's economy and a polarizing effect on its politics. We explore the costs of illegal immigration on business, government, and the children of those who are deported, and we look at why illegal immigrants continue to find their way north in spite of formidable obstacles.