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The Food and Drug Administration aims to evaluate treatments for rare diseases based on plausible evidence that they would work — without requiring a clinical trial first.

The Poway Symphony Orchestra will open its 2025-2026 concert season with "Dvořák in America" on Sunday, Nov. 16, 202,5 at 4 p.m. at the Poway Center for Performing Arts. Under the baton of Conductor John LoPiccolo, the orchestra will present Dvořák's sweeping masterpiece, Symphony No. 9 ("From the New World") and his passionate Cello Concerto, with acclaimed cellist Cello (Qiele) Guo as guest soloist. This concert promises to capture the heart of Dvořák’s time in America — filled with warmth, spirit and unforgettable melody. Visit: https://pcpa.na.ticketsearch.com/sales/salesevent/19149 Poway Symphony Orchestra on Instagram and Facebook

You’re invited to our free Holiday Open House–an annual community event that’s packed with family-friendly activities and holiday cheer. Grab the kiddos and head to The Conrad for a festive evening that’s sure to get everyone into the spirt of the season. Join us from 4 p.m. – 7:30 p.m. at The Conrad! Visit: https://theconrad.org/events/holiday-open-house-2025/ La Jolla Music Society on Instagram and Facebook

What we need as writers is a whole-brain approach to planning our year (and our writing projects) that is visual, flexible, doable, emotional and takes advantage of our strengths and tendencies. This two-hour class will show you how to do things a little differently so you are more focused, balanced, excited, hopeful, and committed to your goals in 2026. We’ll work through the complimentary year planner you will receive and put our plans down in writing to get a head start on the coming year. This is an interactive, hands-on, make-it-happen session that sets you up to create space for writing, visualize your success, and build a plan that pushes you past the things that may have held you back in previous years. Visit: https://writeyourstorynow.org/classes-workshops/2025-12-06-goal-setting-for-writers-with-lee-silber/ SD Writers Ink on Instagram and Facebook

"Miracle", the original holiday-themed pop-up cocktail bar concept, is thrilled to return for the 2025 season. Featuring festive original cocktails, over-the-top decorations, and exciting new mug designs to bring the holiday season to life, this year promises to be one of the best yet. Sippin’ Santa, created by Jeff “Beachbum” Berry, is the tropical offshoot of the famed Miracle pop up bar, the original holiday cocktail bar concept. As in year’s past, the famed mugs and glassware will be available for purchase at all participating bars nationwide. Kicking off November through January, "Miracle" locations in Temecula, Solvang, San Diego, Hermosa Beach, Los Angeles, and Anaheim will feature a holiday oasis with over the top kitschy, festive décor and a themed cocktail menu with fan favorites such as the "Christmapolitan" and "Snowball Old-Fashioned." New this year are "Candy Cane Lane", "Dancing Sugarplums", "Blitzen Barrel", and "Miracle Mouse." Visit: https://www.miraclepopup.com/ Official Miracle Pop Up on Instagram and Facebook

A man with Tourette syndrome shouted a racial slur and other offensive remarks during the BAFTA awards ceremony Sunday. The BBC did not edit out his outbursts in its delayed broadcast.

Los maestros de San Diego cancelaron su huelga planeada para el 26 de febrero después de llegar a un acuerdo tentativo con el distrito escola para aumentar la dotación de personal de educación especial, brindar apoyo y estipendios adicionales a los maestros y asegurar futuros aumentos salariales en espera de la restauración de los fondos estatales.

"Miracle", the original holiday-themed pop-up cocktail bar concept, is thrilled to return for the 2025 season. Featuring festive original cocktails, over-the-top decorations, and exciting new mug designs to bring the holiday season to life, this year promises to be one of the best yet. "Sippin’ Santa," created by Jeff “Beachbum” Berry, is the tropical offshoot of the famed Miracle pop up bar, the original holiday cocktail bar concept. As in year’s past, the famed mugs and glassware will be available for purchase at all participating bars nationwide. Kicking off November through January, "Miracle" locations in Temecula, Solvang, San Diego, Hermosa Beach, Los Angeles, and Anaheim will feature a holiday oasis with over the top kitschy, festive décor and a themed cocktail menu with fan favorites such as the "Christmapolitan" and "Snowball Old-Fashioned." New this year are "Candy Cane Lane," "Dancing Sugarplums," "Blitzen Barrel," and "Miracle Mouse." Step into the holiday magic at "Miracle" at Coaster Saloon! Enjoy a merry mix of seasonal fun, from trivia and paint nights to ornament decorating and gingerbread house making. Wrap up the season with our festive Ugly Sweater Party—cheers to good times and holiday cheer! Visit: https://www.thecoastersaloon.com/happenings/ Official Miracle Pop Up on Instagram and Facebook

California has funded immigrant legal defense against deportation for a decade. Now, more cities and counties are kicking in money, too.

"Miracle", the original holiday-themed pop-up cocktail bar concept, is thrilled to return for the 2025 season. Featuring festive original cocktails, over-the-top decorations, and exciting new mug designs to bring the holiday season to life, this year promises to be one of the best yet. "Sippin’ Santa", created by Jeff “Beachbum” Berry, is the tropical offshoot of the famed Miracle pop up bar, the original holiday cocktail bar concept. As in year’s past, the famed mugs and glassware will be available for purchase at all participating bars nationwide. Kicking off November through January, "Miracle" locations in Temecula, Solvang, San Diego, Hermosa Beach, Los Angeles, and Anaheim will feature a holiday oasis with over the top kitschy, festive décor and a themed cocktail menu with fan favorites such as the "Christmapolitan" and "Snowball Old-Fashioned." New this year are "Candy Cane Lane," "Dancing Sugarplums," "Blitzen Barrel," and "Miracle Mouse." Visit: https://www.miraclepopup.com/ Official Miracle Pop Up on Instagram and Facebook