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How do you feel? Molecules that sense touch and other pressures - Front Row lecture with Ardem Patapoutian, PhD Description: The inner workings of the brain have eluded neuroscientists for ages—including how we perceive sensations such as touch, pain, sound and even blood flow. In this free in-person Front Row lecture, Scripps Research professor and Nobel laureate Ardem Patapoutian will discuss the molecular sensors that enable the mind to interpret different physical and chemical stimuli. These discoveries—which Patapoutian was awarded the 2021 Nobel Prize in Physiology or Medicine for—are helping answer long-standing questions in neuroscience, such as how cells communicate with each other, how we sense our body in time and space, how these sensors impact different diseases and more. ABOUT SCRIPPS RESEARCH Scripps Research is an independent, nonprofit biomedical institute based in La Jolla, California, and ranked one of the most influential in the world for its impact on innovation. The Front Row lecture series, now in its seventh season, offers an exclusive glimpse into groundbreaking scientific discoveries in action. In 2024 we celebrate a century of turning vision into pioneering impact. Reserve your seat today and learn how our scientists remain at the forefront of advancing the future of science and medicine. We hope you’ll join us—in the front row—for the next century of Science Changing Life. Visit: Scripps Research Front Row Lecture Scripps Research on Instagram and Facebook

Join us for an exciting in-person event at the San Diego Made Factory! Get ready to experience a showcase of local talent, creativity, and community spirit. This free, family and dog-friendly event will feature handmade crafts, stunning live art demos, a mini fall photo shoot, live music, drinks, and more. A special guest artist from Alaska, Ashley Lohr, will be demonstrating her craft of torch-firing enamel on copper to all attendees. Don't miss out on this opportunity to support local artists, watch amazing demonstrations, and find one-of-a-kind treasures. Mark your calendars and come enjoy a day filled with creativity, inspiration, and fun at the San Diego Made Factory in Logan Heights, 2031 Commercial St., SD CA 92113.

One month ago today, disaster came to San Diego, when a heavy downpour soaked the city. We hear from some of the people who suffered losses from the storm, to see how their recovery is going. In other news, this week KPBS gathered 15 community leaders from across the South Bay at the San Ysidro library to hear what’s top of mind for them as the election approaches. Plus, we hear from a San Diego librarian who’s had to confront attempted censorship.

The Greater San Diego Music Coterie presents its Annual Messiah Sing- and Play-along at St Bart’s Episcopal Church in Poway in 2 performances, Friday, December 8 at 7 p.m. and Sunday, December 10 at 4 p.m. Accompaniment will be provided by the Greater San Diego Chamber Orchestra under the direction of Dr. Angela Yeung. Instrumentalists interested in playing must contact Dr. Yeung in advance so your part will be ready for you on the day of the concert. Optional rehearsal on Tuesday, December 5, at 7 p.m. at St Bart's Episcopal Church. $10 suggested donation for the rehearsal. $25 suggested donation (or $10 for students) for the performance. Donations by check to either the Greater San Diego Music Coterie or St Bart's Episcopal Church can be tax deductible as allowable by law. For more information visit: gsdmusicoterie.org

At least 10 people were killed in Israel overnight, after multiple Iranian missiles evaded the country's defense systems. Explosions rocked Tehran, where the health ministry said 224 have been killed.

Una nueva ley de California impone penas más severas por agredir a trabajadores de salas de emergencia. Responde a los crecientes ataques a trabajadores de la salud, a pesar de las preocupaciones de los progresistas y los defensores de la reforma penitenciaria

In this class we will focus on the art of paper folding to achieve beautiful paper sculptures. Focusing on cats and dogs, this class is geared towards beginners and intermediate level origami lovers. We will also learn to interpret origami diagrams and to read origami instructions in books in any language. Origami is a beautiful and extensive art that will bring joy and happiness to your life. Like the grandmaster of origami Akira Yoshizawa said, " When the hands are busy, the heart is serene." Immediately after you register, look for a confirmation email and receipt. In the week preceding the class start date, you will receive another email with more details. For more information visit: ljathenaeum.org Stay Connected on Facebook and Instagram

In an historic Brooklyn cemetery, a death educator and a professional knitter have been holding an event series called "Grieving & Weaving" to help people process loss through collective crafting.

California’s power grid is showing a little more stress this week during a persistent hot spell. In other news, a small group of indigenous athletes in San Diego are working to bring back one of the oldest team sports in history, called Ulama. Plus, we have details on some arts events happening this weekend in San Diego County.

The top prize, the 2024 Sweepstakes Trophy, went to the San Diego Zoo for the float “It All Started With a Roar.”