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Drugmakers have brought almost 450 orphan drugs to market and collected rich incentives by doing so. But nearly a third of the medicines aren't new or were repurposed many times for financial gain.

Tim Glover, an administrator at the San Diego County Office of Education, was picked to be Sweetwater's interim superintendent. He replaces Ed Brand, who the school board placed on paid leave Monday.

Is frozen yogurt a weak link in our quest for sustenance and gastronomic pleasure? A Washington, D.C., start-up thinks so, and has just launched a frozen yogurt vending machine to make fro-yo easier.

Prison realignment is shrinking the inmate population at Donovan State Prison in San Diego. The California Department of Corrections and Rehabilitation sent out thousands of lay off warnings last fall, we'll find out how many of the staff at Donovan are at risk of losing their job and how that will affect programs and safety at the Prison.

The Damascus suburb hit by a deadly chemical weapons attack a year ago remains surrounded by Syrian government forces who are still trying to squeeze the rebels out.

Find out why a World Bank data scientist got excited about the global charts of 2016.

Naomi Novik leaves behind the Napoleonic War setting of her previous books for a new stand-alone tale of a village girl, taken by a mysterious magician, who learns she's more than a match for him.

In the children's books, food is practically a supporting character. So why not welcome the poor Baudelaire orphans with a delightfully miserable repast while binge-watching the new show?

In their congressional testimony this week, Trump's would-be advisers said they disagreed with the incoming president on a range of issues, from Russian hacking to NATO to even that border wall.

From unlikely marriages (J-pop and metal? K-pop and hip-hop?) to a case of intoxicated ecstasy, five songs you can't miss hearing.