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SHAKE UP YOUR YULETIDE. Backyard Renaissance's THE SEAFARER is about to make waves. THE SEAFARER by Conor McPherson directed by Kian Kline-Chilton and Hannah Meade Featuring - Richard Baird, John DeCarlo, Francis Gercke, Knight Padilla, and Bruce Turk ------------------------------------------- *Tony, Olivier and Evening Standard Critics' Award Nominated for Best Play* A Devil of a Christmas. Christmas Eve. The coast of North Dublin. Sharky, his blind brother Richard, and old friends Nicky and Ivan gather in a humble abode to kindle tidings of comfort and joy over a friendly card game and the spirits of the season that can only be found at the bottom of a bottle. The night burns brightly. The banter is boisterous and hilarious. Until a mysterious guest, Mr. Lockhart, turns the tables and comes to collect a debt that Sharky never intended to pay. Backyard Renaissance Theatre on Facebook / Instagram

Mexico in a Bottle, San Diego's best celebration of mezcal, tequila, Mexican craft spirits, food, art, music and more returns! Mezcal. Cultura. Herencia. Join us Sunday, October 4 at Bread & Salt Gallery for an afternoon devoted to the great spirits of Mexico. Sip your way through agave spirits while hearing the stories behind them — the producers, the process, the land. You'll also find Mexican whiskey, rum, gin, liqueurs, and more waiting to be discovered. Local restaurants bring the flavor to match, serving up bites paired with cocktails, while art and live music fill the room around you. Because this isn't just about what's in the glass. Every bottle holds a piece of Mexican culture — a living link to history, tradition, food, art, and music. Life and death, distilled. That's what we're here to honor at Mexico in a Bottle. Mezcalistas: Website / Facebook / Instagram

The festival at the Museum of Photographic Arts on July 25 will showcase 27 films from around the world about the joy of biking.

Community-connecting group Walkabout is hosting Thursday Happy Hour Club at 619 Spirits in North Park from 3– 6 p.m. The Walkabout app is free to download and use, and the Happy Hour Club is a way for Walkabouters to get out, meet neighbors, and try a local spot together. In addition to happy hour specials, Walkabouters get 10% off their total bill during this time. 3015 Lincoln Avenue

Accelerating Evolution to Create New Medicines – Front Row lecture with Christian Diercks, PhD Biologic drugs account for about a quarter of recent drug approvals, and most are antibodies. Although antibodies have transformed treatment for many conditions, they mainly work by binding to their targets. But some diseases may benefit more from therapeutics that can selectively alter those targets instead. In this free Front Row lecture, Assistant Professor Christian Diercks will discuss how he harnesses accelerated evolution—a laboratory process that speeds up cycles of genetic change and selection—to engineer therapeutic enzymes that actively break down or modify disease-related molecules. At the center of this work is T7-ORACLE, a synthetic biology platform developed by Diercks’ lab. It continuously introduces mutations into selected genes in bacteria to rapidly evolve proteins, including enzymes, at large scale with minimal researcher intervention. The Diercks lab is using T7-ORACLE to evolve enzymes for the selective degradation of the painful crystals behind gout flares, and to target voltage-gated ion channels involved in chronic pain as a non-addictive alternative to opioid-based therapeutics. ABOUT SCRIPPS RESEARCH Scripps Research is an independent, nonprofit biomedical institute based in La Jolla, California, and ranked one of the most influential in the world for its impact on innovation. The Front Row lecture series, now in its ninth season, offers an exclusive glimpse into groundbreaking scientific discoveries in action. Join us—in the front row. Reserve your seat! Settle into our auditorium for an inspirational, in-person experience, or attend virtually with thousands of people from around the world. Scripps Research on Instagram/Facebook

A report from Labor Department investigators found former Labor Secretary Lori Chavez-DeRemer violated her own department's policy prohibiting harassment. She resigned in April.

Hint: It's not only because California counts slowly.

Join SDSU students, faculty and staff for Truth Before Turnout Social Jeopardy on Thursday, Oct. 22, from 6 to 7 p.m. at Broken Yolk Cafe. Hosted by the SDSU Library and the Glen M. Broom Center for Professional Development in Public Relations, the game blends entertainment with media literacy to make fact-checking feel approachable. Doors open at 5:30 p.m., and teams form at 6 p.m. Questions cover pop culture, media literacy and a Fake or Real round. Teams compete for Truth Before Turnout T-shirts, with more prizes throughout the night. Each round challenges players to put accuracy over popularity by spotting reliable information, evaluating sources and verifying claims before sharing or acting on them. Get ready to look beyond the post and sign up at https://www.eventbrite.com/e/social-jeopardy-night-tickets-2003263079798

The Port of San Diego recognizes the Kumeyaay people by naming a beach at Spanish Landing Park Kumeyaay Beach.

Step back in time at La Valencia Hotel’s 1926 Social Club, featuring a captivating live performance by Cobby Brzeski and her ensemble, Vintage Girl in a Modern World. Join us on the ocean-view Med Patio for an evening that perfectly blends old-world jazz elegance with contemporary flair. The Experience Live Music: Enjoy the nostalgic, soul-stirring sounds of Vintage Girl in a Modern World. Ambiance: Sip 1920s-inspired cocktails and enjoy spirited conversation against the timeless backdrop of "The Pink Lady". Exclusive Dining: Savor a $100 menu for two featuring a Mediterranean spread, skewered shrimp, flat-iron steak, and a decadent tiramisu and raspberry sorbet dessert. Event Logistics Date: Thursday, September 10, 2026 Time: 5:30 p.m. – 8:30 p.m. Location: Med Patio at La Valencia Hotel, 1132 Prospect St, La Jolla, CA Admission: Free entry; open seating is available on a first-come, first-served basis Cobby Brzesk on Facebook / Instagram