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Loneliness takes a toll on many aspects of health, in part because it activates a fight -or-flight immune response. That may have helped ancestors survive lonely exile, but can slowly kill us today.

One comes from a line of New Orleans piano geniuses. Another comes from New York's downtown scene. They bonded over old jazz, and together, inject modern twists into early repertoire.

Perhaps best known for its 2001 hit, "The Middle," the band recently released its eighth studio album, Damage. Lead singer Jim Adkins talks about the band's evolution through two decades together.

There's no shortage of songs about what it means to be a man. But what makes some music sound "manly — and what attracts men to play and listen to certain genres of music? The answers are changing.

Amid confusion and uncertainty about the District's marijuana rules, more and more people are challenging the law's limitations.

Back in the '80s, Ghanaian theater went dark under military curfew. Now, a dapper businessman-turned-playwright is leading an on-stage revival — and doing it with a sense of humor.

The sequel to 1999's album of vintage country duets, In Spite Of Ourselves, will be out Sept. 30. Hear Prine sing the opening song, "Who's Gonna Take The Garbage Out," with Iris DeMent.

After swapping hearing aids for a cochlear implant, Sam Swiller's taste in music shifted dramatically, from grunge rock to folk. Now scientists are trying to improve how implants relay music.

Surveying a year of concerts that took place behind a desk in NPR Music's offices, we offer up highlights from T-Pain to the Pixies to a 12-piece Balkan brass extravaganza.

The Swedish sister act got its start playing feather-light folk-pop confections. But Stay Gold is a statement of staying power; a collection of bright, smart, substantial songs that stick around.