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President Masoud Pezeshkian said Saturday that a demand by the U.S. for an unconditional surrender is a "dream that they should take to their grave." He also apologized for Iran's attacks on regional countries.

The Trump administration says it is "laser focused" and mission driven, but the messaging has been varied. The range of cited motivations for striking Iran now are sometimes at odds with each other.

President Trump is set to gather with Latin American leaders on Saturday at his Miami-area golf club as his administration looks to turn attention to the Western Hemisphere, at least for a moment.

The FDA's controversial vaccine chief, Dr. Vinay Prasad, is leaving the agency. It's the second time he has abruptly departed following decisions involving the review of vaccinations and specialty drugs.

Issa’s abrupt reversal injects more uncertainty in the race for Southern California’s 48th District, which was drastically reshaped in November after voters approved a new U.S. House map for California to favor Democrats.

Supervisor Jim Desmond withdrew from the race for the 49th Congressional District seat and filed to run in the nearby 48th District. The seat is currently held by fellow Republican Darrell Issa.

For many Muslims in San Diego, the war in the Middle East is weighing heavily during Ramadan.

We discuss the San Diego City Council's ordinance to increase the minimum wage for most hospitality workers. Plus, a local news outlet hopes to expand their reach as they welcome a new editor and general manager.

S&S Friendly Ranch began in the 1980s when two siblings set out to build a life in San Diego. Today, their granddaughters and a close friend are carrying that dream forward.

More than 62% of people polled said they "probably or definitely" would not want to ride in a driverless vehicle, the researchers found.